Ketamine and Esketamine (Spravato) for
Severe and Difficult to Treat Depression and Anxiety
Ketamine and Esketamine (Spravato) are new alternatives for treating severe depression and anxiety, approved by the FDA in 2020 to treat suicidal thoughts. Ketamine and esketamine work more quickly than other antidepressants and have been shown to rapidly reduce suicidal thoughts in many people. Because they work differently than other antidepressants, ketamine and esketamine (Spravato) can be effective for people who have not found relief with other medications. If you’ve struggled with depression or anxiety and have tried two or more antidepressants in your current episode without adequate relief, ketamine and eskatamine (Spravato) are important options to consider. Ketamine and Spravato are administered under medical supervision and may be provided through a variety of routes based on patient preference and response, including intranasal, sublingual, intravenous infusions, or intramuscular injections.
Used to treat depression, anxiety, and PTSD, ketamine is administered in our clinic, under medical supervision either through intravenous infusion or intranasal spray. With the help of ketamine, patients report feeling better in as little as six weeks; 40% say their depression is in complete remission.
“Studies from Yale research labs showed that the drug ketamine, which was widely used as anesthesia during surgeries, triggers glutamate production, which, in a complex, cascading series of events, prompts the brain to form new neural connections. This makes the brain more adaptable and able to create new pathways, and gives patients the opportunity to develop more positive thoughts and behaviors. This was an effect that had not been seen before, even with traditional antidepressants.” How New Ketamine Drug Helps with Depression by Jennifer Chen, at yalemedicine.org, March 21, 2019
Dr. Johns was involved with some of the groundbreaking research on ketamine and has been using ketamine therapy to treat depression, anxiety, and PTSD for seven years. Advanced Brain + Body will be one of a few clinics in the Twin Cities to offer patients ketamine treatments paid by insurers in order to make this accessible to the people who need it most.
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